About the Authors

Tadashi Okamura

Contributed equally to this work with: Tadashi Okamura, Rieko Yanobu-Takanashi

Affiliation Division of Animal Model, Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

Rieko Yanobu-Takanashi

Contributed equally to this work with: Tadashi Okamura, Rieko Yanobu-Takanashi

Affiliation Division of Animal Model, Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

Fumihiko Takeuchi

Affiliation Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

Masato Isono

Affiliation Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

Koichi Akiyama

Affiliation Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

Yukiko Shimizu

Affiliation Division of Animal Model, Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

Motohito Goto

Affiliation Division of Animal Model, Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

Yi-Qiang Liang

Affiliation Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

Ken Yamamoto

Affiliation Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan

Tomohiro Katsuya

Affiliations Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan, Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Japan

Akihiro Fujioka

Affiliation Amagasaki Health Medical Foundation, Amagasaki Japan

Keizo Ohnaka

Affiliation Department of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Ryoichi Takayanagi

Affiliation Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Toshio Ogihara

Affiliations Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Japan, Morinomiya University of Medical Sciences, Osaka, Japan

Yukio Yamori

Affiliation Mukogawa Women’s University Institute for World Health Development, Mukogawa, Japan

Norihiro Kato

nokato@ri.ncgm.go.jp

Affiliation Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NK T. Okamura. Performed the experiments: RYT MI KA YS MG YQL. Analyzed the data: T. Okamura FT KY. Contributed reagents/materials/analysis tools: TK AF KO RT T. Ogihara YY. Wrote the paper: NK.