About the Authors

Marco Schlepütz

Affiliation Institute of Pharmacology and Toxicology, RWTH Aachen University, Aachen, Germany

Annette D. Rieg

Affiliation Institute of Pharmacology and Toxicology, RWTH Aachen University, Aachen, Germany

Sophie Seehase

Affiliations Department of Airway Immunology, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany, Encepharm GmbH, Göttingen, Germany

Jan Spillner

Affiliation Department of Cardiothoracic and Vascular Surgery, RWTH Aachen University, Aachen, Germany

Alberto Perez-Bouza

Affiliation Institute of Pathology, RWTH Aachen University, Aachen, Germany

Till Braunschweig

Affiliation Institute of Pathology, RWTH Aachen University, Aachen, Germany

Thomas Schroeder

Affiliation Department of Surgery, Luisenhospital Aachen, Aachen, Germany

Marc Bernau

Affiliation Institute of Pharmacology and Toxicology, RWTH Aachen University, Aachen, Germany

Verena Lambermont

Affiliation School of Oncology and Developmental Biology, School of Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands

Christina Schlumbohm

Affiliation Encepharm GmbH, Göttingen, Germany

Katherina Sewald

Affiliation Department of Airway Immunology, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany

Rüdiger Autschbach

Affiliation Department of Cardiothoracic and Vascular Surgery, RWTH Aachen University, Aachen, Germany

Armin Braun

Affiliation Department of Airway Immunology, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany

Boris W. Kramer

Affiliation School of Oncology and Developmental Biology, School of Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands

Stefan Uhlig

Affiliation Institute of Pharmacology and Toxicology, RWTH Aachen University, Aachen, Germany

Christian Martin

chmartin@ukaachen.de

Affiliation Institute of Pharmacology and Toxicology, RWTH Aachen University, Aachen, Germany

Competing Interests

CS is currently employee at Encepharm GmbH. With respect to the current study CS took responsibility for the supply with NHP material from the German Primate Center Göttingen, a non-commercial institution. There are no competing interests by Encepharm GmbH relating to employment, consultancy, patents, products in development or marketed products. Hence, CS's employment at Encepharm GmbH does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MS SU CM. Performed the experiments: MS MB. Analyzed the data: MS SU CM. Contributed reagents/materials/analysis tools: MS ADR SS JS AP TB TS VL CS KS RA AB BWK SU CM. Wrote the paper: MS SU CM. Read and revised the manuscript: MS ADR SS JS AP TB TS VL CS KS RA AB BWK SU CM.