Computational Modeling Reveals Dendritic Origins of GABAA-Mediated Excitation in CA1 Pyramidal Neurons

Naomi Lewin; Emre Aksay; Colleen E. Clancy

doi:10.1371/journal.pone.0047250

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Peer-reviewed

Research Article

Computational Modeling Reveals Dendritic Origins of GABA_A-Mediated Excitation in CA1 Pyramidal Neurons

Naomi Lewin,

Affiliations Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, New York, United States of America, Tri-Institutional MD-PhD Program, Physiology, Biophysics and Systems Biology Graduate Program, Department of Pharmacology, University of California Davis, Davis, California, United States of America
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Emre Aksay,

Affiliation Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, New York, United States of America
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Colleen E. Clancy

* E-mail: ceclancy@ucdavis.edu

Affiliation Tri-Institutional MD-PhD Program, Physiology, Biophysics and Systems Biology Graduate Program, Department of Pharmacology, University of California Davis, Davis, California, United States of America
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Computational Modeling Reveals Dendritic Origins of GABA_A-Mediated Excitation in CA1 Pyramidal Neurons

Naomi Lewin,
Emre Aksay,
Colleen E. Clancy

Published: October 12, 2012
https://doi.org/10.1371/journal.pone.0047250

About the Authors

Naomi Lewin

Affiliations Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, New York, United States of America, Tri-Institutional MD-PhD Program, Physiology, Biophysics and Systems Biology Graduate Program, Department of Pharmacology, University of California Davis, Davis, California, United States of America

Emre Aksay

Affiliation Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, New York, United States of America

Colleen E. Clancy

* E-mail: ceclancy@ucdavis.edu

Affiliation Tri-Institutional MD-PhD Program, Physiology, Biophysics and Systems Biology Graduate Program, Department of Pharmacology, University of California Davis, Davis, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NL EA CC. Performed the experiments: NL. Analyzed the data: NL EA CC. Contributed reagents/materials/analysis tools: NL EA CC. Wrote the paper: NL EA CC.

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Depolarization
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Neuronal dendrites
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Membrane potential
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Chlorides
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Gamma-aminobutyric acid
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Pyramidal cells
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Interneurons
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Hyperpolarization
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