ERK-Mediated Activation of Fas Apoptotic Inhibitory Molecule 2 (Faim2) Prevents Apoptosis of 661W Cells in a Model of Detachment-Induced Photoreceptor Cell Death

Cagri G. Besirli; Qiong-Duon Zheng; David M. Reed; David N. Zacks

doi:10.1371/journal.pone.0046664

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Peer-reviewed

Research Article

ERK-Mediated Activation of Fas Apoptotic Inhibitory Molecule 2 (Faim2) Prevents Apoptosis of 661W Cells in a Model of Detachment-Induced Photoreceptor Cell Death

Cagri G. Besirli,

Affiliation Department of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, United States of America
⨯
Qiong-Duon Zheng,

Affiliation Department of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, United States of America
⨯
David M. Reed,

Affiliation Department of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, United States of America
⨯
David N. Zacks

* E-mail: davzacks@umich.edu

Affiliation Department of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, United States of America
⨯

ERK-Mediated Activation of Fas Apoptotic Inhibitory Molecule 2 (Faim2) Prevents Apoptosis of 661W Cells in a Model of Detachment-Induced Photoreceptor Cell Death

Cagri G. Besirli,
Qiong-Duon Zheng,
David M. Reed,
David N. Zacks

Published: September 28, 2012
https://doi.org/10.1371/journal.pone.0046664

About the Authors

Cagri G. Besirli

Affiliation Department of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, United States of America

Qiong-Duon Zheng

Affiliation Department of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, United States of America

David M. Reed

Affiliation Department of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, United States of America

David N. Zacks

* E-mail: davzacks@umich.edu

Affiliation Department of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CGB DNZ. Performed the experiments: CGB QZ DMR DNZ. Analyzed the data: CGB QZ DMR DNZ. Wrote the paper: CGB DNZ.

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Apoptosis
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Photoreceptors
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ERK signaling cascade
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Retinal detachment
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c-Jun N-terminal kinase signaling cascade
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Signal inhibition
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Small interfering RNA
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Stress signaling cascade
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