PI3Kγ Drives Priming and Survival of Autoreactive CD4+ T Cells during Experimental Autoimmune Encephalomyelitis

Iain Comerford; Wendel Litchfield; Ervin Kara; Shaun R. McColl

doi:10.1371/journal.pone.0045095

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Open Access

Peer-reviewed

Research Article

PI3Kγ Drives Priming and Survival of Autoreactive CD4⁺ T Cells during Experimental Autoimmune Encephalomyelitis

Iain Comerford ,

Contributed equally to this work with: Iain Comerford, Wendel Litchfield

* E-mail: iain.comerford@adelaide.edu.au

Affiliation The Chemokine Biology Laboratory, the School of Molecular & Biomedical Science, the University of Adelaide, Adelaide, South Australia, Australia
⨯
Wendel Litchfield ,

Contributed equally to this work with: Iain Comerford, Wendel Litchfield

Affiliation The Chemokine Biology Laboratory, the School of Molecular & Biomedical Science, the University of Adelaide, Adelaide, South Australia, Australia
⨯
Ervin Kara,

Affiliation The Chemokine Biology Laboratory, the School of Molecular & Biomedical Science, the University of Adelaide, Adelaide, South Australia, Australia
⨯
Shaun R. McColl

Affiliation The Chemokine Biology Laboratory, the School of Molecular & Biomedical Science, the University of Adelaide, Adelaide, South Australia, Australia
⨯

PI3Kγ Drives Priming and Survival of Autoreactive CD4⁺ T Cells during Experimental Autoimmune Encephalomyelitis

Iain Comerford,
Wendel Litchfield,
Ervin Kara,
Shaun R. McColl

Published: September 13, 2012
https://doi.org/10.1371/journal.pone.0045095

About the Authors

Iain Comerford

Contributed equally to this work with: Iain Comerford, Wendel Litchfield

* E-mail: iain.comerford@adelaide.edu.au

Affiliation The Chemokine Biology Laboratory, the School of Molecular & Biomedical Science, the University of Adelaide, Adelaide, South Australia, Australia

Wendel Litchfield

Contributed equally to this work with: Iain Comerford, Wendel Litchfield

Affiliation The Chemokine Biology Laboratory, the School of Molecular & Biomedical Science, the University of Adelaide, Adelaide, South Australia, Australia

Ervin Kara

Affiliation The Chemokine Biology Laboratory, the School of Molecular & Biomedical Science, the University of Adelaide, Adelaide, South Australia, Australia

Shaun R. McColl

Affiliation The Chemokine Biology Laboratory, the School of Molecular & Biomedical Science, the University of Adelaide, Adelaide, South Australia, Australia

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IC WL EK SRM. Performed the experiments: IC WL EK. Analyzed the data: IC WL EK. Wrote the paper: IC WL EK SRM.

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T cell receptors
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