About the Authors

Makiko Miyamoto

Affiliations Department of Anesthesiology, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan, Department of Physiology, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan

Yoshiyuki Tsuboi

Affiliations Department of Physiology, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan, Division of Functional Morphology, Dental Research Center, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan

Kuniya Honda

Affiliations Department of Physiology, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan, Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan

Masayuki Kobayashi

Affiliation Department of Pharmacology, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan

Kogo Takamiya

Affiliation Department of Medical Sciences, Section of Integrative Physiology Faculty of medicine, Graduate School of Medicine University of Miyazaki, Kihara, Kiyotake-cho, Miyazaki-shi, Miyazaki, Japan

Richard L. Huganir

Affiliation Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Masahiro Kondo

Affiliations Department of Physiology, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan, Division of Functional Morphology, Dental Research Center, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan

Masamichi Shinoda

Affiliations Department of Physiology, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan, Division of Functional Morphology, Dental Research Center, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan

Barry J. Sessle

Affiliation Department of Physiology, University of Toronto, Toronto, Ontario, Canada

Ayano Katagiri

Affiliation Department of Physiology, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan

Daiju Kita

Affiliation Department of Physiology, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan

Ikuko Suzuki

Affiliation Department of Physiology, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan

Yoshiyuki Oi

Affiliation Department of Anesthesiology, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan

Koichi Iwata

iwata-k@dent.nihon-u.ac.jp

Affiliations Department of Physiology, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan, Division of Functional Morphology, Dental Research Center, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KI. Performed the experiments: MM YT KH M. Kobayashi M. Kondo MS DK AK IS. Analyzed the data: MM YT KH M. Kobayashi M. Kondo MS. Contributed reagents/materials/analysis tools: KH. Wrote the paper: MM KI. Contributed to discussion and reviewed/edited the manuscript: KT RLH BJS YO.