Crystal Structure of the Sema-PSI Extracellular Domain of Human RON Receptor Tyrosine Kinase

Kinlin L. Chao; I-Wei Tsai; Chen Chen; Osnat Herzberg

doi:10.1371/journal.pone.0041912

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Peer-reviewed

Research Article

Crystal Structure of the Sema-PSI Extracellular Domain of Human RON Receptor Tyrosine Kinase

Kinlin L. Chao,

Affiliation Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland, United States of America
⨯
I-Wei Tsai,

Affiliation Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland, United States of America
⨯
Chen Chen,

Affiliation Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland, United States of America
⨯
Osnat Herzberg

* E-mail: osnat@umd.edu

Affiliations Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland, United States of America, Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland, United States of America
⨯

Crystal Structure of the Sema-PSI Extracellular Domain of Human RON Receptor Tyrosine Kinase

Kinlin L. Chao,
I-Wei Tsai,
Chen Chen,
Osnat Herzberg

Published: July 25, 2012
https://doi.org/10.1371/journal.pone.0041912

About the Authors

Kinlin L. Chao

Affiliation Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland, United States of America

I-Wei Tsai

Affiliation Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland, United States of America

Chen Chen

Affiliation Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland, United States of America

Osnat Herzberg

* E-mail: osnat@umd.edu

Affiliations Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland, United States of America, Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KLC OH. Performed the experiments: KLC CC. Analyzed the data: KLC OH. Contributed reagents/materials/analysis tools: KLC IWT. Wrote the paper: KLC OH.

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Crystals
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Crystal structure
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Disulfide bonds
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Dimerization
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Dimers
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Tyrosine kinases
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Protein kinase signaling cascade
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Cysteine
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