About the Authors

Yamil Gerena

Affiliations NeuroAIDS Specialized Neuroscience Research Program, University of Puerto Rico, San Juan, Puerto Rico, United States of America, School of Pharmacy, University of Puerto Rico, San Juan, Puerto Rico, United States of America

Richard L. Skolasky

Affiliation Department of Orthopaedic Surgery, Johns Hopkins University, Baltimore, Maryland, United States of America

Joyce M. Velez

Affiliation NeuroAIDS Specialized Neuroscience Research Program, University of Puerto Rico, San Juan, Puerto Rico, United States of America

Dianedis Toro-Nieves

Affiliation NeuroAIDS Specialized Neuroscience Research Program, University of Puerto Rico, San Juan, Puerto Rico, United States of America

Raul Mayo

Affiliations NeuroAIDS Specialized Neuroscience Research Program, University of Puerto Rico, San Juan, Puerto Rico, United States of America, Departments of Physical Medicine and Rehabilitation, University of Puerto Rico, San Juan, Puerto Rico, United States of America

Avindra Nath

Affiliation Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

Valerie Wojna

valerie.wojna1@upr.edu

Affiliations NeuroAIDS Specialized Neuroscience Research Program, University of Puerto Rico, San Juan, Puerto Rico, United States of America, Internal Medicine Neurology Division, University of Puerto Rico, San Juan, Puerto Rico, United States of America

Competing Interests

A patent disclosure has been submitted to our institution, The University of Puerto Rico (UPR), for the procedures used in the methodology of our study and has been accepted for further evaluation by our institution's Intellectual Property Office. The UPR has filed a patent application for the invention at the United States Patent & Trademark Office entitled: “Soluble insulin receptor as a biomarker for HIV-associated neurocognitive disorder (HAND)”. Therefore, the invention is patent pending. It is the UPR policy not to publish its patent applications including the application numbers. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: YG VW. Performed the experiments: YG DTN. Analyzed the data: RLS JMV. Contributed reagents/materials/analysis tools: YG RM VW. Wrote the paper: YG RLS JMV RM AN VW.