About the Authors

Bettina Platt

b.platt@abdn.ac.uk

Affiliation School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom

Benjamin Drever

Affiliation School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom

David Koss

Affiliation School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom

Sandra Stoppelkamp

Affiliation School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom

Amar Jyoti

Affiliation School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom

Andrea Plano

Affiliation School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom

Aneli Utan

Affiliation School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom

Georgina Merrick

Affiliation School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom

Duncan Ryan

Affiliation School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom

Valeria Melis

Affiliation School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom

Hong Wan

Affiliation Translational & Molecular Medicine, Pfizer BioTherapeutics, Collegeville, Pennsylvania, United States of America

Marco Mingarelli

Affiliation School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom

Emanuele Porcu

Affiliation School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom

Louise Scrocchi

Affiliation Amorfix Life Sciences, Mississauga, Ontario, Canada

Andy Welch

Affiliation School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom

Gernot Riedel

Affiliation School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom

Competing Interests

The authors have read the journal's policy and report the following conflicts: a patent has been submitted on the PLB1 knock-in mouse (US 12/833474). HW is an employee of Pfizer BioTherapeutics, LS is an employee of Amofrix Life Sciences. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Analyzed the data: BP GR BD DR AJ VM GM AP AW. Wrote the paper: BP GR. Designed all experiments and conducted the final data analyses: BP GR. Contributed to the study design: HW. In vitro electrophysiology: BD. Tissue analyses, genotyping and histology: DK SS. Behaviour: DR EP GM AU VM. EEG/activity: AJ AP. PET imaging: AW MM. Amyloid assay: LS.