About the Authors

R. Adam Horch

Affiliations Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, United States of America, Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, United States of America

Daniel F. Gochberg

Affiliations Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, United States of America, Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America

Jeffry S. Nyman

jeffry.s.nyman@vanderbilt.edu (JSN); mark.does@vanderbilt.edu (MDD)

Affiliations Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, United States of America, VA Tennessee Valley Healthcare System, Nashville, Tennessee, United States of America, Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Center for Bone Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

Mark D. Does

jeffry.s.nyman@vanderbilt.edu (JSN); mark.does@vanderbilt.edu (MDD)

Affiliations Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, United States of America, Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, United States of America, Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America, Department of Electrical Engineering, Vanderbilt University, Nashville, Tennessee, United States of America

Competing Interests

The authors have filed a provisional patent on inventions related to the findings presented in this manuscript. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: RAH DFG JSN MDD. Performed the experiments: RAH. Analyzed the data: RAH. Contributed reagents/materials/analysis tools: RAH DFG JSN MDD. Wrote the paper: JSN MDD. Supervised the project: JSN MDD.