About the Authors

Ryszard M. Pluta

rysiek@ninds.nih.gov

Affiliation Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

Edward H. Oldfield

Affiliations Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America, Department of Neurological Surgery, University of Virginia Health Sciences Center, University of Virginia, Charlottesville, Virginia, United States of America

Kamran D. Bakhtian

Affiliation Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

Ali Reza Fathi

Affiliations Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America, Department of Neurosurgery, Kantonsspital Aarau AG, Aarau, Switzerland

René K. Smith

Affiliation Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

Hetty L. DeVroom

Affiliation Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

Masoud Nahavandi

Affiliation Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

Sukyung Woo

Affiliation Molecular Pharmacology Section and Clinical Pharmacology Program, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

William D. Figg

Affiliation Molecular Pharmacology Section and Clinical Pharmacology Program, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Russell R. Lonser

Affiliation Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

Competing Interests

A patent titled “Treatment of Specific Cardiovascular Conditions with Nitrite” has been granted for the following co-inventors: Mark T. Gladwin, Alan N. Schechter, Christian Hunter, Ryszard M. Pluta, and Edward H. Oldfield. This research was performed under a cooperative research and development agreement between the National Institute of Neurological Disorders and Stroke at the National Institutes of Health and Hope Pharmaceuticals, Inc. This does not alter our adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: RP EHO RRL. Performed the experiments: RP RKS HLD MN. Analyzed the data: RP KDB ARF SW WDF. Contributed reagents/materials/analysis tools: RP KDB ARF. Wrote the paper: RP EHO KDB ARF RRL. Obtained funding, administrative, technical, or material support, supervision: EHO. Acquisition of data, analysis and interpretation of data, drafting of the manuscript, critical revision of the manuscript for important intellectual content, administrative, technical, or material support: KDB ARF. Acquisition of data, administrative, technical, or material support: RKS HLDV. Acquisition of data: MN. Analysis and interpretation of data, critical revision of the manuscript for important intellectual, statistical analysis: SW WDF. Conception and design, analysis and interpretation of data, drafting of the manuscript, critical revision of the manuscript for important intellectual content, obtaining funding, administrative, technical, or material support, supervision: RRL.