Lack of nAChR Activity Depresses Cochlear Maturation and Up-Regulates GABA System Components: Temporal Profiling of Gene Expression in α9 Null Mice

Sevin Turcan; Donna K. Slonim; Douglas E. Vetter

doi:10.1371/journal.pone.0009058

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Open Access

Peer-reviewed

Research Article

Lack of nAChR Activity Depresses Cochlear Maturation and Up-Regulates GABA System Components: Temporal Profiling of Gene Expression in α9 Null Mice

Sevin Turcan,

Affiliations Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, United States of America, Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, United States of America
⨯
Donna K. Slonim,

Affiliation Department of Computer Science, Tufts University, Medford, Massachusetts, United States of America
⨯
Douglas E. Vetter

* E-mail: douglas.vetter@tufts.edu

Affiliation Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, United States of America
⨯

Lack of nAChR Activity Depresses Cochlear Maturation and Up-Regulates GABA System Components: Temporal Profiling of Gene Expression in α9 Null Mice

Sevin Turcan,
Donna K. Slonim,
Douglas E. Vetter

Published: February 4, 2010
https://doi.org/10.1371/journal.pone.0009058

About the Authors

Sevin Turcan

Affiliations Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, United States of America, Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, United States of America

Donna K. Slonim

Affiliation Department of Computer Science, Tufts University, Medford, Massachusetts, United States of America

Douglas E. Vetter

* E-mail: douglas.vetter@tufts.edu

Affiliation Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ST DEV. Performed the experiments: ST. Analyzed the data: ST DKS DEV. Contributed reagents/materials/analysis tools: DKS DEV. Wrote the paper: ST DKS DEV.

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Gene expression
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Cochlea
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Synapses
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Cholinergics
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Microarrays
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Nicotinic acetylcholine receptors
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Immunoprecipitation
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CREB signaling
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