Differential Expression of hERG1 Channel Isoforms Reproduces Properties of Native IKr and Modulates Cardiac Action Potential Characteristics

Anders Peter Larsen; Søren-Peter Olesen

doi:10.1371/journal.pone.0009021

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Open Access

Peer-reviewed

Research Article

Differential Expression of hERG1 Channel Isoforms Reproduces Properties of Native I_Kr and Modulates Cardiac Action Potential Characteristics

Anders Peter Larsen ,

* E-mail: spo@mfi.ku.dk

Affiliation The Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Søren-Peter Olesen

Affiliation The Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
⨯

Differential Expression of hERG1 Channel Isoforms Reproduces Properties of Native I_Kr and Modulates Cardiac Action Potential Characteristics

Anders Peter Larsen,
Søren-Peter Olesen

Published: February 2, 2010
https://doi.org/10.1371/journal.pone.0009021

About the Authors

Anders Peter Larsen

* E-mail: spo@mfi.ku.dk

Affiliation The Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

Søren-Peter Olesen

Affiliation The Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: APL. Performed the experiments: APL. Analyzed the data: APL. Contributed reagents/materials/analysis tools: SPO. Wrote the paper: APL SPO.

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Oocytes
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Action potentials
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Markov models
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Heart
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Curve fitting
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