About the Authors
- Yuan-Ping Pang
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* E-mail: pang@mayo.edu (YPP); james.schmidt@det.amedd.army.mil (JJS)
Affiliation Computer-Aided Molecular Design Laboratory, Mayo Clinic, Rochester, Minnesota, United States of America
- Anuradha Vummenthala
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Affiliation Computer-Aided Molecular Design Laboratory, Mayo Clinic, Rochester, Minnesota, United States of America
- Rajesh K. Mishra
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Affiliation Computer-Aided Molecular Design Laboratory, Mayo Clinic, Rochester, Minnesota, United States of America
- Jewn Giew Park
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Affiliation Computer-Aided Molecular Design Laboratory, Mayo Clinic, Rochester, Minnesota, United States of America
- Shaohua Wang
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Affiliation Computer-Aided Molecular Design Laboratory, Mayo Clinic, Rochester, Minnesota, United States of America
- Jon Davis
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Current address: Integrated Toxicology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
Affiliation Division of Biochemistry, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
- Charles B. Millard
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Current address: United States Army Medical Research & Materiel Command, Fort Detrick, Maryland, United States of America
Affiliation Division of Biochemistry, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
- James J. Schmidt
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* E-mail: pang@mayo.edu (YPP); james.schmidt@det.amedd.army.mil (JJS)
Affiliation Integrated Toxicology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
Competing Interests
All authors are inventors of a filed provisional patent application titled “Small-Molecule Botulinum Toxin Inhibitors” that is related to the inhibitors described in this paper, but this does not alter the adherence to all the PLoS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: YPP CBM JJS JD. Devised the syntheses of 4, 10b, 11, and AHP: AV. Devised the syntheses of 2, 5, 10b, 11, 14, and AHP: RKM. Devised the syntheses of 3, 6, 7, and 8: JGP. Devised the synthesis of 9: SW. Performed the experiments RKM AV JGP SW YPP JJS JD. Analyzed the data: all authors. Wrote the paper: YPP. Contributed with revisions: all authors.