About the Authors

Julia Romanova

Contributed equally to this work with: Julia Romanova, Brigitte M. Krenn

Affiliation Avir Green Hills Biotechnology AG, Vienna, Austria

Brigitte M. Krenn

Contributed equally to this work with: Julia Romanova, Brigitte M. Krenn

Affiliation Avir Green Hills Biotechnology AG, Vienna, Austria

Markus Wolschek

Affiliations Avir Green Hills Biotechnology AG, Vienna, Austria, Department of Surgery, University of Vienna Medical School, Vienna, Austria

Boris Ferko

Affiliation Avir Green Hills Biotechnology AG, Vienna, Austria

Ekaterina Romanovskaja-Romanko

Affiliation Influenza Research Institute, Russian Academy of Medical Sciences, St. Petersburg, Russia

Alexander Morokutti

Affiliation Avir Green Hills Biotechnology AG, Vienna, Austria

Anna-Polina Shurygina

Affiliation Influenza Research Institute, Russian Academy of Medical Sciences, St. Petersburg, Russia

Sabine Nakowitsch

Affiliation Avir Green Hills Biotechnology AG, Vienna, Austria

Tanja Ruthsatz

Affiliation Avir Green Hills Biotechnology AG, Vienna, Austria

Bettina Kiefmann

Affiliation Avir Green Hills Biotechnology AG, Vienna, Austria

Ulrich König

Affiliation Avir Green Hills Biotechnology AG, Vienna, Austria

Michael Bergmann

Affiliation Department of Surgery, University of Vienna Medical School, Vienna, Austria

Monika Sachet

Affiliation Department of Surgery, University of Vienna Medical School, Vienna, Austria

Shobana Balasingam

Affiliation Retroscreen Virology Ltd., Centre for Infectious Diseases, Bart's and the London, Queen Mary's School of Medicine and Dentistry, London, United Kingdom

Alexander Mann

Affiliation Retroscreen Virology Ltd., Centre for Infectious Diseases, Bart's and the London, Queen Mary's School of Medicine and Dentistry, London, United Kingdom

John Oxford

Affiliation Retroscreen Virology Ltd., Centre for Infectious Diseases, Bart's and the London, Queen Mary's School of Medicine and Dentistry, London, United Kingdom

Martin Slais

Affiliation BioTest Ltd., Konarovice, Czech Republic

Oleg Kiselev

Affiliation Influenza Research Institute, Russian Academy of Medical Sciences, St. Petersburg, Russia

Thomas Muster

Affiliations Avir Green Hills Biotechnology AG, Vienna, Austria, Division of General Dermatology, Department of Dermatology, Medical University of Vienna, Vienna, Austria

Andrej Egorov

a.egorov@greenhillsbiotech.com

Affiliation Avir Green Hills Biotechnology AG, Vienna, Austria

Competing Interests

Avir Green Hills Biotechnology is a privately held biopharmaceutical company based in Vienna which draws its own knowledge in virology to develop and commercialize a vaccine approach targeting seasonal and pandemic influenza disease among other products in the pipeline. The primary objective of the projects FLUVACC (LSHB-CT-2005-518281) and Intranasal H5 Vaccine (SP5B-CT-2007-044512) related to this manuscript is the development of an intranasal live attenuated vaccine targeting pandemic influenza disease. Both projects are executed in collaboration with international partners, which form a consortium that is regulated by the projects' corresponding consortium agreements. The consortium agreement regulates the operational execution of the project, including protection, exploitation and use of knowledge. IIPR rights related to this manuscript are covered by the following IP rights: DelNs1 mutants are covered by patents from Avir Green Hills and Mount Sinai School of Medicine. Patent applications covering the technology platform of the influenza virus expression construct and virus amplification procedure are fully owned by Avir Green Hills Biotechnology. The patent application concerning the purification process is co-owned with Biaseparations d.r.o. All individuals named in the authorship list of this manuscript are either employees of Avir Green Hills Biotechnology or of organizations that have entered an agreement within the European grants mentioned above.

Author Contributions

Conceived and designed the experiments: JR BMK MW BF TR MMB SB AM JO MS OK TM AE. Performed the experiments: BMK MW BF ERR AM APS SN BK UK MS MS. Analyzed the data: JR BMK BF ERR AM APS SN TR BK UK MS TM. Contributed reagents/materials/analysis tools: MW MMB. Wrote the paper: JR BMK AE.