About the Authors

John Paul SanGiovanni

Contributed equally to this work with: John Paul SanGiovanni, Dan E. Arking

jpsangio@post.harvard.edu

Affiliation National Eye Institute (NEI)/National Institutes of Health (NIH), Bethesda, Maryland, United States of America

Dan E. Arking

Contributed equally to this work with: John Paul SanGiovanni, Dan E. Arking

Affiliation McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

Sudha K. Iyengar

Affiliation Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America

Michael Elashoff

Affiliation CardioDx, Palo Alto, California, United States of America

Traci E. Clemons

Affiliation The EMMES Corp., Rockville, Maryland, United States of America

George F. Reed

Affiliation National Eye Institute (NEI)/National Institutes of Health (NIH), Bethesda, Maryland, United States of America

Alice K. Henning

Affiliation The EMMES Corp., Rockville, Maryland, United States of America

Theru A. Sivakumaran

Affiliation Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America

Xuming Xu

Affiliation Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, United States of America

Andrew DeWan

Affiliation Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, United States of America

Elvira Agrón

Affiliation National Eye Institute (NEI)/National Institutes of Health (NIH), Bethesda, Maryland, United States of America

Elena Rochtchina

Affiliation Centre for Vision Research, Department of Ophthalmology, Westmead Millennium Institute, University of Sydney, Sydney, Australia

Carolyn M. Sue

Affiliation University of Sydney Kolling Institute for Medical Research, Sydney, Australia

Jie Jin Wang

Affiliation Centre for Vision Research, Department of Ophthalmology, Westmead Millennium Institute, University of Sydney, Sydney, Australia

Paul Mitchell

Affiliation Centre for Vision Research, Department of Ophthalmology, Westmead Millennium Institute, University of Sydney, Sydney, Australia

Josephine Hoh

Affiliation Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, United States of America

Peter J. Francis

Affiliation Macular Degeneration Center, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States of America

Michael L. Klein

Affiliation Macular Degeneration Center, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States of America

Emily Y. Chew

Affiliation National Eye Institute (NEI)/National Institutes of Health (NIH), Bethesda, Maryland, United States of America

Aravinda Chakravarti

Affiliation McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

Competing Interests

Aravinda Chakravarti is a paid member of the Scientific Advisory Board of Affymetrix, a role that is managed by the Committee on Conflict of Interest of the Johns Hopkins University School of Medicine.

Author Contributions

Conceived and designed the experiments: JPS DEA SKI ME TEC JH PJF MK EYC AC. Performed the experiments: DEA SKI TAS XX AD CMS. Analyzed the data: JPS DEA ME TEC EA ER PJF. Contributed reagents/materials/analysis tools: JPS DEA SKI TEC GFR AKH ER CMS JJW PM JH PJF MK EYC AC. Wrote the paper: JPS DEA SKI ME TEC GFR AKH EA JJW PM JH PJF MK EYC AC. Constructed original AREDS phenotype datasets: AKH.