Modular Mass Spectrometric Tool for Analysis of Composition and Phosphorylation of Protein Complexes

Justin D. Blethrow; Chao Tang; Changhui Deng; Andrew N. Krutchinsky

doi:10.1371/journal.pone.0000358

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Open Access

Peer-reviewed

Research Article

Modular Mass Spectrometric Tool for Analysis of Composition and Phosphorylation of Protein Complexes

Justin D. Blethrow,

Affiliation Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, United States of America
⨯
Chao Tang,

Affiliation XProteo Inc, New York, New York, United States of America
⨯
Changhui Deng,

Affiliation Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America
⨯
Andrew N. Krutchinsky

*To whom correspondence should be addressed. E-mail: krutcha@picasso.ucsf.edu

Affiliation Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America
⨯

Modular Mass Spectrometric Tool for Analysis of Composition and Phosphorylation of Protein Complexes

Justin D. Blethrow,
Chao Tang,
Changhui Deng,
Andrew N. Krutchinsky

Published: April 4, 2007
https://doi.org/10.1371/journal.pone.0000358

About the Authors

Justin D. Blethrow

Affiliation Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, United States of America

Chao Tang

Affiliation XProteo Inc, New York, New York, United States of America

Changhui Deng

Affiliation Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

Andrew N. Krutchinsky

*To whom correspondence should be addressed. E-mail: krutcha@picasso.ucsf.edu

Affiliation Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

Competing Interests

The authors of the article, except AK, have no competing financial interests. AK declares a competing financial interest. ThermoElectron and Perkin Elmer license the rights to produce some parts of the MALDI interfaces for vMALDI-IT and prOTOF mass spectrometers. AK is a co-author of several patents covering these parts.

Author Contributions

Conceived and designed the experiments: AK. Performed the experiments: AK JB. Analyzed the data: AK JB. Contributed reagents/materials/analysis tools: AK JB CD. Wrote the paper: AK JB. Other: Produced XProteo search engine for identification of proteins: CT.

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Mass spectrometers
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Antigen-presenting cells
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Phosphorylation
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Saccharomyces cerevisiae
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Protein complexes
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Yeast
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Information retrieval
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Signal to noise ratio
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