Single Doses up to 800 mg of E-52862 Do Not Prolong the QTc Interval – A Retrospective Validation by Pharmacokinetic-Pharmacodynamic Modelling of Electrocardiography Data Utilising the Effects of a Meal on QTc to Demonstrate ECG Assay Sensitivity

• Jörg Täubel ,

  * E-mail: j.taubel@sgul.ac.uk

  Affiliations Richmond Pharmacology Ltd., St George's University of London, Cranmer Terrace, London, United Kingdom, Cardiovascular and Cell Sciences Research Institute, St George's University of London, Cranmer Terrace, London, United Kingdom

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• Georg Ferber,

  Affiliation Statistik Georg Ferber GmbH, Cagliostrostrasse, Riehen, Switzerland

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• Ulrike Lorch,

  Affiliation Richmond Pharmacology Ltd., St George's University of London, Cranmer Terrace, London, United Kingdom

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• Duolao Wang,

  Affiliation Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

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• Mariano Sust,

  Affiliation Department of Clinical Investigation, ESTEVE Research & Development, Av. Mare de Déu de Montserrat, Barcelona, Spain

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• A. John Camm

  Affiliation Cardiovascular and Cell Sciences Research Institute, St George's University of London, Cranmer Terrace, London, United Kingdom

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