Down-Regulation of mir-221 and mir-222 Restrain Prostate Cancer Cell Proliferation and Migration That Is Partly Mediated by Activation of SIRT1

Xiao Yang; Yingmei Yang; Rong Gan; Lingxu Zhao; Wei Li; Huaibin Zhou; Xiaojuan Wang; Jianxin Lu; Qing H. Meng

doi:10.1371/journal.pone.0098833

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Open Access

Peer-reviewed

Research Article

Down-Regulation of mir-221 and mir-222 Restrain Prostate Cancer Cell Proliferation and Migration That Is Partly Mediated by Activation of SIRT1

Xiao Yang,

Affiliation Wenzhou Medical University School of Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang, China
⨯
Yingmei Yang,

Affiliation Wenzhou Medical University School of Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang, China
⨯
Rong Gan,

Affiliation Wenzhou Medical University School of Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang, China
⨯
Lingxu Zhao,

Affiliation Wenzhou Medical University School of Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang, China
⨯
Wei Li,

Affiliations Wenzhou Medical University School of Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang, China, Key Laboratory of Laboratory Medicine, Ministry of Education, Wenzhou, Zhejiang, China, Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou, Zhejiang, China
⨯
Huaibin Zhou,

Affiliations Wenzhou Medical University School of Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang, China, Key Laboratory of Laboratory Medicine, Ministry of Education, Wenzhou, Zhejiang, China, Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou, Zhejiang, China
⨯
Xiaojuan Wang,

Affiliations Wenzhou Medical University School of Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang, China, Department of Clinical Laboratory Medicine, Jinhua People's Hospital, Jinhua, Zhejiang, China
⨯
Jianxin Lu,

Affiliations Wenzhou Medical University School of Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang, China, Key Laboratory of Laboratory Medicine, Ministry of Education, Wenzhou, Zhejiang, China, Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou, Zhejiang, China
⨯
Qing H. Meng

Affiliation Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯

Down-Regulation of mir-221 and mir-222 Restrain Prostate Cancer Cell Proliferation and Migration That Is Partly Mediated by Activation of SIRT1

Xiao Yang,
Yingmei Yang,
Rong Gan,
Lingxu Zhao,
Wei Li,
Huaibin Zhou,
Xiaojuan Wang,
Jianxin Lu,
Qing H. Meng

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Published: June 3, 2014
https://doi.org/10.1371/journal.pone.0098833

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Transfection
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Prostate cancer
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Apoptosis
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Cell proliferation
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Cell migration
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MicroRNAs
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Luciferase
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Cancer cell migration
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