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Calcium Binding to Beta-2-Microglobulin at Physiological Ph Drives the Occurrence of Conformational Changes Which Cause the Protein to Precipitate into Amorphous Forms That Subsequently Transform into Amyloid Aggregates

  • Sukhdeep Kumar,

    Affiliation Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Mohali, SAS Nagar, Punjab, India

  • Prerna Sharma,

    Affiliations Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Mohali, SAS Nagar, Punjab, India, Council of Scientific and Industrial Research, Institute of Microbial Technology (CSIR-IMTECH), Chandigarh, India

  • Kanika Arora,

    Affiliation Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Mohali, SAS Nagar, Punjab, India

  • Manoj Raje,

    Affiliation Council of Scientific and Industrial Research, Institute of Microbial Technology (CSIR-IMTECH), Chandigarh, India

  • Purnananda Guptasarma

    guptasarma@iisermohali.ac.in

    Affiliation Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Mohali, SAS Nagar, Punjab, India

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