Triple Immunoglobulin Gene Knockout Transchromosomic Cattle: Bovine Lambda Cluster Deletion and Its Effect on Fully Human Polyclonal Antibody Production

• Hiroaki Matsushita,

  Affiliations Sanford Applied Biosciences L.L.C., Sioux Falls, South Dakota, United States of America, Hematech, Inc., Sioux Falls, South Dakota, United States of America

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• Akiko Sano,

  Affiliations Kyowa Hakko Kirin, Co., Ltd., Chiyoda-ku, Tokyo, Japan, Hematech, Inc., Sioux Falls, South Dakota, United States of America

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• Hua Wu,

  Affiliations Sanford Applied Biosciences L.L.C., Sioux Falls, South Dakota, United States of America, Hematech, Inc., Sioux Falls, South Dakota, United States of America

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• Jin-an Jiao,

  Affiliations Sanford Applied Biosciences L.L.C., Sioux Falls, South Dakota, United States of America, Hematech, Inc., Sioux Falls, South Dakota, United States of America

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• Poothappillai Kasinathan,

  Affiliations Trans Ova Genetics, Sioux Center, Iowa, United States of America, Hematech, Inc., Sioux Falls, South Dakota, United States of America

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• Eddie J. Sullivan ,

  * E-mail: eddie.sullivan@sanfordhealth.org (ES); zonda.wang@usu.edu (ZW)

  Affiliations Sanford Applied Biosciences L.L.C., Sioux Falls, South Dakota, United States of America, Hematech, Inc., Sioux Falls, South Dakota, United States of America

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• Zhongde Wang ,

  * E-mail: eddie.sullivan@sanfordhealth.org (ES); zonda.wang@usu.edu (ZW)

  Affiliations Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, Utah, United States of America, Hematech, Inc., Sioux Falls, South Dakota, United States of America

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• Yoshimi Kuroiwa

  Affiliations Kyowa Hakko Kirin, Co., Ltd., Chiyoda-ku, Tokyo, Japan, Hematech, Inc., Sioux Falls, South Dakota, United States of America

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