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MiR-34a/c-Dependent PDGFR-α/β Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer

  • Michela Garofalo ,

    Contributed equally to this work with: Michela Garofalo, Young-Jun Jeon

    carlo.croce@osumc.edu (CC); michela.garofalo@osumc.edu (MG)

    Affiliation Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America

  • Young-Jun Jeon ,

    Contributed equally to this work with: Michela Garofalo, Young-Jun Jeon

    Affiliation Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America

  • Gerard J. Nuovo,

    Affiliations Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America, Phylogeny, Inc., Columbus, Ohio, United States of America

  • Justin Middleton,

    Affiliation Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America

  • Paola Secchiero,

    Affiliation Department of Morphology and Embryology, Human Anatomy Section, University of Ferrara, Ferrara, Italy

  • Pooja Joshi,

    Affiliation Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America

  • Hansjuerg Alder,

    Affiliation Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America

  • Natalya Nazaryan,

    Affiliation Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America

  • Gianpiero Di Leva,

    Affiliation Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America

  • Giulia Romano,

    Affiliation Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America

  • Melissa Crawford,

    Affiliation Pulmonary, Allergy, Critical Care and Sleep Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States of America

  • Patrick Nana-Sinkam,

    Affiliation Pulmonary, Allergy, Critical Care and Sleep Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States of America

  • Carlo M. Croce

    carlo.croce@osumc.edu (CC); michela.garofalo@osumc.edu (MG)

    Affiliation Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America

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