Robust Immunity and Heterologous Protection against Influenza in Mice Elicited by a Novel Recombinant NP-M2e Fusion Protein Expressed in E. coli

Wenling Wang; Baoying Huang; Tao Jiang; Xiuping Wang; Xiangrong Qi; Yingying Gao; Wenjie Tan; Li Ruan

doi:10.1371/journal.pone.0052488

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Peer-reviewed

Research Article

Robust Immunity and Heterologous Protection against Influenza in Mice Elicited by a Novel Recombinant NP-M2e Fusion Protein Expressed in E. coli

Wenling Wang ,

Contributed equally to this work with: Wenling Wang, Baoying Huang

Affiliation National Institute for Viral Disease Control & Prevention, Chinese Center for Disease Control and Prevention, China CDC, Beijing, People’s Republic of China
⨯
Baoying Huang ,

Contributed equally to this work with: Wenling Wang, Baoying Huang

Affiliation National Institute for Viral Disease Control & Prevention, Chinese Center for Disease Control and Prevention, China CDC, Beijing, People’s Republic of China
⨯
Tao Jiang,

Affiliation National Institute for Viral Disease Control & Prevention, Chinese Center for Disease Control and Prevention, China CDC, Beijing, People’s Republic of China
⨯
Xiuping Wang,

Affiliation National Institute for Viral Disease Control & Prevention, Chinese Center for Disease Control and Prevention, China CDC, Beijing, People’s Republic of China
⨯
Xiangrong Qi,

Affiliation National Institute for Viral Disease Control & Prevention, Chinese Center for Disease Control and Prevention, China CDC, Beijing, People’s Republic of China
⨯
Yingying Gao,

Affiliation National Institute for Viral Disease Control & Prevention, Chinese Center for Disease Control and Prevention, China CDC, Beijing, People’s Republic of China
⨯
Wenjie Tan,

Affiliation National Institute for Viral Disease Control & Prevention, Chinese Center for Disease Control and Prevention, China CDC, Beijing, People’s Republic of China
⨯
Li Ruan

* E-mail: ruanl@bbn.cn

Affiliation National Institute for Viral Disease Control & Prevention, Chinese Center for Disease Control and Prevention, China CDC, Beijing, People’s Republic of China
⨯

Robust Immunity and Heterologous Protection against Influenza in Mice Elicited by a Novel Recombinant NP-M2e Fusion Protein Expressed in E. coli

Wenling Wang,
Baoying Huang,
Tao Jiang,
Xiuping Wang,
Xiangrong Qi,
Yingying Gao,
Wenjie Tan,
Li Ruan

x

Published: December 21, 2012
https://doi.org/10.1371/journal.pone.0052488

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Enzyme-linked immunoassays
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Immune response
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Influenza A virus
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Recombinant proteins
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