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Open Access

Peer-reviewed

Research Article

Humanized Mouse Model of Skin Inflammation Is Characterized by Disturbed Keratinocyte Differentiation and Influx of IL-17A Producing T Cells

  • Vivian L. de Oliveira,

    Affiliation Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Romy R. M. C. Keijsers,

    Affiliations Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, Dermatology Department, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Peter C. M. van de Kerkhof,

    Affiliation Dermatology Department, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Marieke M. B. Seyger,

    Affiliation Dermatology Department, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Esther Fasse,

    Affiliation Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Lars Svensson,

    Affiliation Department of Disease Pharmacology, LEO Pharma, Ballerup, Denmark

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  • Markus Latta,

    Affiliation Department of Disease Pharmacology, LEO Pharma, Ballerup, Denmark

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  • Hanne Norsgaard,

    Affiliation Department of Molecular Biomedicine, LEO Pharma, Ballerup, Denmark

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  • Tord Labuda,

    Affiliation Department of Molecular Biomedicine, LEO Pharma, Ballerup, Denmark

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  • Pieter Hupkens,

    Affiliation Department of Plastic Surgery Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Piet E. J. van Erp,

    Affiliation Dermatology Department, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Irma Joosten,

    Affiliation Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Hans J. P. M. Koenen

    h.koenen@labgk.umcn.nl

    Affiliation Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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