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GABAA Receptor α Subunits Differentially Contribute to Diazepam Tolerance after Chronic Treatment

  • Christiaan H. Vinkers ,

    c.h.vinkers@uu.nl

    Affiliations Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands, Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

  • Ruud van Oorschot,

    Affiliation Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

  • Elsebet Ø. Nielsen,

    Affiliation NeuroSearch A/S, NsDiscovery, Ballerup, Denmark

  • James M. Cook,

    Affiliation Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, United States of America

  • Henrik H. Hansen,

    Affiliations NeuroSearch A/S, NsDiscovery, Ballerup, Denmark, Gubra ApS, Hørsholm, Denmark

  • Lucianne Groenink,

    Affiliation Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

  • Berend Olivier,

    Affiliations Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America

  • Naheed R. Mirza

    Affiliations NeuroSearch A/S, NsDiscovery, Ballerup, Denmark, Aniona ApS, Ballerup, Denmark

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