Mouse-Adapted H9N2 Influenza A Virus PB2 Protein M147L and E627K Mutations Are Critical for High Virulence

Jingjing Wang; Yipeng Sun; Qi Xu; Yuanyuan Tan; Juan Pu; Hanchun Yang; Earl G. Brown; Jinhua Liu

doi:10.1371/journal.pone.0040752

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Peer-reviewed

Research Article

Mouse-Adapted H9N2 Influenza A Virus PB2 Protein M147L and E627K Mutations Are Critical for High Virulence

Jingjing Wang ,

Contributed equally to this work with: Jingjing Wang, Yipeng Sun

Affiliation Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
⨯
Yipeng Sun ,

Contributed equally to this work with: Jingjing Wang, Yipeng Sun

Affiliation Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
⨯
Qi Xu,

Affiliation Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
⨯
Yuanyuan Tan,

Affiliation Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
⨯
Juan Pu,

Affiliation Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
⨯
Hanchun Yang,

Affiliation Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
⨯
Earl G. Brown,

Affiliations Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada, Emerging Pathogens Research Centre, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
⨯
Jinhua Liu

* E-mail: ljh@cau.edu.cn

Affiliations Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China, The Shandong Animal Disease Control Center, Jinan, China
⨯

Mouse-Adapted H9N2 Influenza A Virus PB2 Protein M147L and E627K Mutations Are Critical for High Virulence

Jingjing Wang,
Yipeng Sun,
Qi Xu,
Yuanyuan Tan,
Juan Pu,
Hanchun Yang,
Earl G. Brown,
Jinhua Liu

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Published: July 10, 2012
https://doi.org/10.1371/journal.pone.0040752

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