Small Molecules with Similar Structures Exhibit Agonist, Neutral Antagonist or Inverse Agonist Activity toward Angiotensin II Type 1 Receptor

• Shin-ichiro Miura ,

  Contributed equally to this work with: Shin-ichiro Miura, Yoshihiro Kiya

  * E-mail: miuras@cis.fukuoka-u.ac.jp

  Affiliations Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan, Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Ohio, United States of America

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• Yoshihiro Kiya ,

  Contributed equally to this work with: Shin-ichiro Miura, Yoshihiro Kiya

  Affiliation Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan

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• Hiroyuki Hanzawa,

  Affiliation Research & Development Division, Daiichi Sankyo Company, Ltd., Tokyo, Japan

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• Naoki Nakao,

  Affiliation Research & Development Division, Daiichi Sankyo Company, Ltd., Tokyo, Japan

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• Masahiro Fujino,

  Affiliation Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan

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• Satoshi Imaizumi,

  Affiliation Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan

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• Yoshino Matsuo,

  Affiliation Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan

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• Hiroaki Yanagisawa,

  Affiliation Research & Development Division, Daiichi Sankyo Company, Ltd., Tokyo, Japan

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• Hiroyuki Koike,

  Affiliation Research & Development Division, Daiichi Sankyo Company, Ltd., Tokyo, Japan

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• Issei Komuro,

  Affiliation Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan

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• Sadashiva S. Karnik,

  Affiliation Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Ohio, United States of America

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• Keijiro Saku

  Affiliation Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan

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