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Open Access

Peer-reviewed

Research Article

Probiotic Bacteria Produce Conjugated Linoleic Acid Locally in the Gut That Targets Macrophage PPAR γ to Suppress Colitis

  • Josep Bassaganya-Riera ,

    jbassaga@vt.edu.

    Affiliation Nutritional Immunology and Molecular Medicine Laboratory, Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America

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  • Monica Viladomiu,

    Affiliation Nutritional Immunology and Molecular Medicine Laboratory, Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America

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  • Mireia Pedragosa,

    Affiliation Nutritional Immunology and Molecular Medicine Laboratory, Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America

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  • Claudio De Simone,

    Affiliation Experimental Medicine, L'Aquila University, L'Aquila, Italy

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  • Adria Carbo,

    Affiliation Nutritional Immunology and Molecular Medicine Laboratory, Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America

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  • Rustem Shaykhutdinov,

    Affiliation Department of Biological Sciences, Metabolomics Research Centre, and Department of Medicine, Division of Gastroenterology, University of Calgary, Alberta, Canada

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  • Christian Jobin,

    Affiliation Department of Medicine, Division of Gastroenterology and Hepatology and Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Janelle C. Arthur,

    Affiliation Department of Medicine, Division of Gastroenterology and Hepatology and Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Benjamin A. Corl,

    Affiliation Department of Dairy Science, Virginia Tech, Blacksburg, Virginia, United States of America

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  • Hans Vogel,

    Affiliation Department of Biological Sciences, Metabolomics Research Centre, and Department of Medicine, Division of Gastroenterology, University of Calgary, Alberta, Canada

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  • Martin Storr,

    Affiliations Department of Biological Sciences, Metabolomics Research Centre, and Department of Medicine, Division of Gastroenterology, University of Calgary, Alberta, Canada, Department of Medicine, Division of Gastroenterology, University of Munich, Munich, Germany

    ⨯
  • Raquel Hontecillas

    Affiliation Nutritional Immunology and Molecular Medicine Laboratory, Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America

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