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Open Access

Peer-reviewed

Research Article

CNS Penetration of Intrathecal-Lumbar Idursulfase in the Monkey, Dog and Mouse: Implications for Neurological Outcomes of Lysosomal Storage Disorder

  • Pericles Calias ,

    Contributed equally to this work with: Pericles Calias, Mikhail Papisov

    pcalias@shire.com

    Affiliation Shire Human Genetic Therapies, Inc., Lexington, Massachusetts, United States of America

    ⨯
  • Mikhail Papisov ,

    Contributed equally to this work with: Pericles Calias, Mikhail Papisov

    Affiliations Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Radiology, Harvard Medical School, Cambridge, Massachusetts, United States of America, Department of Nuclear Medicine, Shriners Burns Hospital, Boston, Massachusetts, United States of America

    ⨯
  • Jing Pan,

    Affiliation Shire Human Genetic Therapies, Inc., Lexington, Massachusetts, United States of America

    ⨯
  • Nancy Savioli,

    Affiliation Shire Human Genetic Therapies, Inc., Lexington, Massachusetts, United States of America

    ⨯
  • Vasily Belov,

    Affiliations Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Radiology, Harvard Medical School, Cambridge, Massachusetts, United States of America, Department of Nuclear Medicine, Shriners Burns Hospital, Boston, Massachusetts, United States of America

    ⨯
  • Yan Huang,

    Affiliation Shire Human Genetic Therapies, Inc., Lexington, Massachusetts, United States of America

    ⨯
  • Jason Lotterhand,

    Affiliation Shire Human Genetic Therapies, Inc., Lexington, Massachusetts, United States of America

    ⨯
  • Mary Alessandrini,

    Affiliation Shire Human Genetic Therapies, Inc., Lexington, Massachusetts, United States of America

    ⨯
  • Nan Liu,

    Affiliation Shire Human Genetic Therapies, Inc., Lexington, Massachusetts, United States of America

    ⨯
  • Alan J. Fischman,

    Affiliations Department of Radiology, Harvard Medical School, Cambridge, Massachusetts, United States of America, Department of Nuclear Medicine, Shriners Burns Hospital, Boston, Massachusetts, United States of America

    ⨯
  • Jan L. Powell,

    Affiliation Shire Human Genetic Therapies, Inc., Lexington, Massachusetts, United States of America

    ⨯
  • Michael W. Heartlein

    Affiliation Shire Human Genetic Therapies, Inc., Lexington, Massachusetts, United States of America

    ⨯

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