A Potent Inhibitor of SIK2, 3, 3′, 7-Trihydroxy-4′-Methoxyflavon (4′-O-Methylfisetin), Promotes Melanogenesis in B16F10 Melanoma Cells

• Ayako Kumagai,

  Affiliations Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Osaka, Japan, Laboratory of Cell Signaling and Metabolic Disease, National Institute of Biomedical Innovation, Osaka, Japan

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• Nanao Horike,

  Current address: Laboratory of Animal Models for Human Diseases, National Institute of Biomedical Innovation, Osaka, Japan

  Affiliations Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Osaka, Japan, Laboratory of Cell Signaling and Metabolic Disease, National Institute of Biomedical Innovation, Osaka, Japan

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• Yudai Satoh,

  Affiliation Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Osaka, Japan

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• Tatsuya Uebi,

  Affiliation Laboratory of Cell Signaling and Metabolic Disease, National Institute of Biomedical Innovation, Osaka, Japan

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• Tsutomu Sasaki,

  Affiliation Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan

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• Yumi Itoh,

  Affiliation Laboratory of Cell Signaling and Metabolic Disease, National Institute of Biomedical Innovation, Osaka, Japan

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• Yoshiyuki Hirata,

  Affiliation Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Osaka, Japan

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• Kozue Uchio-Yamada,

  Affiliation Laboratory of Animal Models for Human Diseases, National Institute of Biomedical Innovation, Osaka, Japan

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• Kazuo Kitagawa,

  Affiliation Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan

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• Shinichi Uesato,

  Affiliation Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Osaka, Japan

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• Hidehisa Kawahara,

  Affiliation Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Osaka, Japan

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• Hiroshi Takemori ,

  * E-mail: takemori@nibio.go.jp

  Affiliation Laboratory of Cell Signaling and Metabolic Disease, National Institute of Biomedical Innovation, Osaka, Japan

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• Yasuo Nagaoka

  Affiliation Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Osaka, Japan

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