Evidence That Gene Activation and Silencing during Stem Cell Differentiation Requires a Transcriptionally Paused Intermediate State

• Jonathan L. Golob,

  Affiliation Departments of Pathology and Bioengineering, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, United States of America

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• Roshan M. Kumar,

  Affiliation Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

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• Matthew G. Guenther,

  Affiliation Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

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• Lil M. Pabon,

  Affiliation Departments of Pathology and Bioengineering, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, United States of America

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• Gabriel A. Pratt,

  Affiliation Departments of Pathology and Bioengineering, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, United States of America

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• Jeanne F. Loring,

  Affiliation Center for Regenerative Medicine, The Scripps Research Institute, La Jolla, California, United States of America

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• Louise C. Laurent,

  Affiliations Center for Regenerative Medicine, The Scripps Research Institute, La Jolla, California, United States of America, Department of Reproductive Medicine, University of California San Diego, San Diego, California, United States of America

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• Richard A. Young,

  Affiliation Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

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• Charles E. Murry

  * E-mail: murry@u.washington.edu

  Affiliation Departments of Pathology and Bioengineering, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, United States of America

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