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Open Access

Peer-reviewed

Research Article

Combination CTLA-4 Blockade and 4-1BB Activation Enhances Tumor Rejection by Increasing T-Cell Infiltration, Proliferation, and Cytokine Production

  • Michael A. Curran,

    Affiliation Howard Hughes Medical Institute, Department of Immunology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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  • Myoungjoo Kim,

    Affiliation Howard Hughes Medical Institute, Department of Immunology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

    ⨯
  • Welby Montalvo,

    Affiliation Howard Hughes Medical Institute, Department of Immunology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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  • Aymen Al-Shamkhani,

    Affiliation Cancer Sciences Division, University of Southampton School of Medicine, Southampton General Hospital, Southampton, United Kingdom

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  • James P. Allison

    allisonj@mskcc.org

    Affiliation Howard Hughes Medical Institute, Department of Immunology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

    ⨯

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