A Tumor-Associated Mutation of FYVE-CENT Prevents Its Interaction with Beclin 1 and Interferes with Cytokinesis

Antonia P. Sagona; Ioannis P. Nezis; Kristi G. Bache; Kaisa Haglund; Anne Cathrine Bakken; Rolf I. Skotheim; Harald Stenmark

doi:10.1371/journal.pone.0017086

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Peer-reviewed

Research Article

A Tumor-Associated Mutation of FYVE-CENT Prevents Its Interaction with Beclin 1 and Interferes with Cytokinesis

Antonia P. Sagona,

Affiliations Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway, Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
⨯
Ioannis P. Nezis,

Affiliations Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway, Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
⨯
Kristi G. Bache,

Affiliations Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway, Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
⨯
Kaisa Haglund,

Affiliations Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway, Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
⨯
Anne Cathrine Bakken,

Affiliations Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway, Department of Cancer Prevention, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
⨯
Rolf I. Skotheim,

Affiliations Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway, Department of Cancer Prevention, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
⨯
Harald Stenmark

* E-mail: stenmark@ulrik.uio.no

Affiliations Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway, Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
⨯

A Tumor-Associated Mutation of FYVE-CENT Prevents Its Interaction with Beclin 1 and Interferes with Cytokinesis

Antonia P. Sagona,
Ioannis P. Nezis,
Kristi G. Bache,
Kaisa Haglund,
Anne Cathrine Bakken,
Rolf I. Skotheim,
Harald Stenmark

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Published: March 24, 2011
https://doi.org/10.1371/journal.pone.0017086

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Breast cancer
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Cytokinesis
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Small interfering RNA
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Immunoprecipitation
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HeLa cells
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Glutathione chromatography
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