High ALDH Activity Identifies Chemotherapy-Resistant Ewing's Sarcoma Stem Cells That Retain Sensitivity to EWS-FLI1 Inhibition

• Ola Awad ,

  Contributed equally to this work with: Ola Awad, Jason T. Yustein, Preeti Shah

  Current address: Department of Histology and Genetics, School of Medicine, Suez Canal University, Ismailia, Egypt

  Affiliation Division of Pediatric Oncology, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Jason T. Yustein ,

  Contributed equally to this work with: Ola Awad, Jason T. Yustein, Preeti Shah

  Current address: Department of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America

  Affiliation Division of Pediatric Oncology, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Preeti Shah ,

  Contributed equally to this work with: Ola Awad, Jason T. Yustein, Preeti Shah

  Affiliation Division of Pediatric Oncology, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Naheed Gul,

  Affiliation Division of Pediatric Oncology, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Varalakshmi Katuri,

  Affiliation Division of Pediatric Oncology, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Alison O'Neill,

  Affiliations Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D.C., United States of America, Department of Pediatrics, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D.C., United States of America

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• Yali Kong,

  Affiliation Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D.C., United States of America

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• Milton L. Brown,

  Affiliation Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D.C., United States of America

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• Jeffrey A. Toretsky ,

  ¶These authors also contributed equally to this work.

  Affiliations Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D.C., United States of America, Department of Pediatrics, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D.C., United States of America

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• David M. Loeb

  * E-mail: loebda@jhmi.edu

  ¶These authors also contributed equally to this work.

  Affiliation Division of Pediatric Oncology, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America

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