Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes

Lorella Marselli; Jeffrey Thorne; Sonika Dahiya; Dennis C. Sgroi; Arun Sharma; Susan Bonner-Weir; Piero Marchetti; Gordon C. Weir

doi:10.1371/journal.pone.0011499

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Peer-reviewed

Research Article

Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes

Lorella Marselli,

Affiliation Section on Islet Transplantation and Cell Biology, Research Division, Joslin Diabetes Center and the Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Jeffrey Thorne,

Affiliation Section on Islet Transplantation and Cell Biology, Research Division, Joslin Diabetes Center and the Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Sonika Dahiya,

Affiliation Molecular Pathology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Dennis C. Sgroi,

Affiliation Molecular Pathology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Arun Sharma,

Affiliation Section on Islet Transplantation and Cell Biology, Research Division, Joslin Diabetes Center and the Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Susan Bonner-Weir,

Affiliation Section on Islet Transplantation and Cell Biology, Research Division, Joslin Diabetes Center and the Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Piero Marchetti,

Affiliation Section of Endocrinology and Metabolism of Organ Transplantation, Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
⨯
Gordon C. Weir

* E-mail: gordon.weir@joslin.harvard.edu

Affiliation Section on Islet Transplantation and Cell Biology, Research Division, Joslin Diabetes Center and the Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes

Lorella Marselli,
Jeffrey Thorne,
Sonika Dahiya,
Dennis C. Sgroi,
Arun Sharma,
Susan Bonner-Weir,
Piero Marchetti,
Gordon C. Weir

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Published: July 13, 2010
https://doi.org/10.1371/journal.pone.0011499

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Gene expression
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Diabetes mellitus
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Type 2 diabetes
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Transcription factors
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Apoptosis
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Insulin signaling
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RNA amplification
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