Antibodies Targeted to the Brain with Image-Guided Focused Ultrasound Reduces Amyloid-β Plaque Load in the TgCRND8 Mouse Model of Alzheimer's Disease

• Jessica F. Jordão,

  Affiliations Brain Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada, Imaging, Sunnybrook Research Institute, Toronto, Ontario, Canada, Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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• Carlos A. Ayala-Grosso,

  Affiliations Brain Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada, Unidad de Biología Molecular, Facultad de Farmacia, Universidad Central de Venezuela, Los Chaguaramos, Caracas, Venezuela

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• Kelly Markham,

  Affiliation Brain Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada

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• Yuexi Huang,

  Affiliation Imaging, Sunnybrook Research Institute, Toronto, Ontario, Canada

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• Rajiv Chopra,

  Affiliations Imaging, Sunnybrook Research Institute, Toronto, Ontario, Canada, Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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• JoAnne McLaurin,

  Affiliations Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada, Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada

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• Kullervo Hynynen ,

  Contributed equally to this work with: Kullervo Hynynen, Isabelle Aubert

  * E-mail: khynynen@sri.utoronto.ca (KH); isabelle.aubert@sri.utoronto.ca (IA)

  Affiliations Imaging, Sunnybrook Research Institute, Toronto, Ontario, Canada, Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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• Isabelle Aubert

  Contributed equally to this work with: Kullervo Hynynen, Isabelle Aubert

  * E-mail: khynynen@sri.utoronto.ca (KH); isabelle.aubert@sri.utoronto.ca (IA)

  Affiliations Brain Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada, Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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