Phosphodiesterase Type 5 Inhibitors Increase Herceptin Transport and Treatment Efficacy in Mouse Metastatic Brain Tumor Models

• Jinwei Hu ,

  Contributed equally to this work with: Jinwei Hu, Julia Y. Ljubimova

  Affiliation Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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• Julia Y. Ljubimova ,

  Contributed equally to this work with: Jinwei Hu, Julia Y. Ljubimova

  * E-mail: ljubimovaj@cshs.org

  Affiliation Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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• Satoshi Inoue,

  Affiliation Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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• Bindu Konda,

  Affiliation Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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• Rameshwar Patil,

  Affiliation Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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• Hui Ding,

  Affiliation Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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• Andres Espinoza,

  Affiliation Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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• Kolja A. Wawrowsky,

  Affiliation Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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• Chirag Patil,

  Affiliation Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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• Alexander V. Ljubimov,

  Affiliations Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America

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• Keith L. Black

  Affiliation Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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