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Open Access

Peer-reviewed

Research Article

Characterization of a Natural Mutator Variant of Human DNA Polymerase λ which Promotes Chromosomal Instability by Compromising NHEJ

  • Gloria Terrados,

    Affiliation Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain

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  • Jean-Pascal Capp,

    Affiliation Laboratoire d'Ingénierie des Sistèmes Biologiques et des Procédés. UMR INSA/CNRS, Toulouse, France

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  • Yvan Canitrot,

    Affiliation CNRS-IPBS (Institute of Pharmacology and Structural Biology), Toulouse, France

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  • Miguel García-Díaz,

    Affiliations Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America

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  • Katarzyna Bebenek,

    Affiliation Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America

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  • Tomas Kirchhoff,

    Affiliations Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain, Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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  • Alberto Villanueva,

    Affiliation Laboratory of Translational Research, Institut Català d'Oncologia-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain

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  • François Boudsocq,

    Affiliation CNRS-IPBS (Institute of Pharmacology and Structural Biology), Toulouse, France

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  • Valérie Bergoglio,

    Affiliation CNRS-IPBS (Institute of Pharmacology and Structural Biology), Toulouse, France

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  • Christophe Cazaux,

    Affiliation CNRS-IPBS (Institute of Pharmacology and Structural Biology), Toulouse, France

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  • Thomas A. Kunkel,

    Affiliation Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America

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  • Jean-Sébastien Hoffmann ,

    lblanco@cbm.uam.es (LB); jseb@ipbs.fr (JSH)

    Affiliation CNRS-IPBS (Institute of Pharmacology and Structural Biology), Toulouse, France

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  • Luis Blanco

    lblanco@cbm.uam.es (LB); jseb@ipbs.fr (JSH)

    Affiliation Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain

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