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Open Access

Peer-reviewed

Research Article

A Francisella tularensis Schu S4 Purine Auxotroph Is Highly Attenuated in Mice but Offers Limited Protection against Homologous Intranasal Challenge

  • Roger D. Pechous,

    Affiliation Department of Microbiology and Molecular Genetics and Center for Biopreparedness and Infectious Diseases, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America

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  • Travis R. McCarthy,

    Affiliation Department of Microbiology and Molecular Genetics and Center for Biopreparedness and Infectious Diseases, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America

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  • Nrusingh P. Mohapatra,

    Affiliation Center for Microbial Interface Biology, Department of Molecular Biology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America

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  • Shilpa Soni,

    Affiliation Center for Microbial Interface Biology, Department of Molecular Biology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America

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  • Renee M. Penoske,

    Affiliation Department of Microbiology and Molecular Genetics and Center for Biopreparedness and Infectious Diseases, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America

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  • Nita H. Salzman,

    Affiliations Department of Microbiology and Molecular Genetics and Center for Biopreparedness and Infectious Diseases, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America

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  • Dara W. Frank,

    Affiliation Department of Microbiology and Molecular Genetics and Center for Biopreparedness and Infectious Diseases, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America

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  • John S. Gunn,

    Affiliation Center for Microbial Interface Biology, Department of Molecular Biology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America

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  • Thomas C. Zahrt

    tzahrt@mcw.edu

    Affiliation Department of Microbiology and Molecular Genetics and Center for Biopreparedness and Infectious Diseases, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America

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