Primary Role of Functional Ischemia, Quantitative Evidence for the Two-Hit Mechanism, and Phosphodiesterase-5 Inhibitor Therapy in Mouse Muscular Dystrophy

• Akihiro Asai,

  Affiliations Department of Anesthesiology and Critical Care, Shriners Hospital for Children, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

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• Nita Sahani,

  Affiliation Department of Anesthesiology and Critical Care, Shriners Hospital for Children, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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• Masao Kaneki,

  Affiliation Department of Anesthesiology and Critical Care, Shriners Hospital for Children, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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• Yasuyoshi Ouchi,

  Affiliation Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

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• J. A. Jeevendra Martyn,

  Affiliation Department of Anesthesiology and Critical Care, Shriners Hospital for Children, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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• Shingo Egusa Yasuhara

  *To whom correspondence should be addressed. E-mail: shingo_yasuhara@yahoo.com

  Affiliation Department of Anesthesiology and Critical Care, Shriners Hospital for Children, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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