BACE1 Inhibition Induces a Specific Cerebrospinal Fluid β-Amyloid Pattern That Identifies Drug Effects in the Central Nervous System

• Niklas Mattsson ,

  * E-mail: niklas.mattsson@neuro.gu.se (NM); erik.portelius@neuro.gu.se (EP)

  Affiliation Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden

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• Lawrence Rajendran,

  Affiliation Systems and Cell Biology of Neurodegeneration, Division of Psychiatry Research, University of Zurich, Zurich, Switzerland

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• Henrik Zetterberg,

  Affiliation Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden

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• Mikael Gustavsson,

  Affiliation Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden

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• Ulf Andreasson,

  Affiliation Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden

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• Maria Olsson,

  Affiliation Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden

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• Gunnar Brinkmalm,

  Affiliation Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden

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• Johan Lundkvist,

  Affiliation Innovative Medicines, Central Nervous System and Pain iMed, Department of Neuroscience, AstraZeneca R&D, Södertälje, Sweden

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• Laura H. Jacobson,

  Affiliation Neuroscience Discovery, Novartis Institutes for BioMedical Research, Basel, Switzerland

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• Ludovic Perrot,

  Affiliation Neuroscience Discovery, Novartis Institutes for BioMedical Research, Basel, Switzerland

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• Ulf Neumann,

  Affiliation Neuroscience Discovery, Novartis Institutes for BioMedical Research, Basel, Switzerland

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• Herman Borghys,

  Affiliation Neuroscience Therapeutic Area, Janssen Research and Development, Beerse, Belgium

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• Marc Mercken,

  Affiliation Neuroscience Therapeutic Area, Janssen Research and Development, Beerse, Belgium

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• Deborah Dhuyvetter,

  Affiliation Neuroscience Therapeutic Area, Janssen Research and Development, Beerse, Belgium

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• Fredrik Jeppsson,

  Affiliation Innovative Medicines, Central Nervous System and Pain iMed, Department of Neuroscience, AstraZeneca R&D, Södertälje, Sweden

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• Kaj Blennow,

  Affiliation Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden

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•  [ ... ],
• Erik Portelius

  * E-mail: niklas.mattsson@neuro.gu.se (NM); erik.portelius@neuro.gu.se (EP)

  Affiliation Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden

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