Frequent Alteration of MLL3 Frameshift Mutations in Microsatellite Deficient Colorectal Cancer

Yoshiyuki Watanabe; Ryan J. Castoro; Hyun Soo Kim; Brittany North; Ritsuko Oikawa; Tetsuya Hiraishi; Saira S. Ahmed; Woonbok Chung; Mee-Yon Cho; Minoru Toyota; Fumio Itoh; Marcos R. H. Estecio; Lanlan Shen; Jaroslav Jelinek; Jean-Pierre J. Issa

doi:10.1371/journal.pone.0023320

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Peer-reviewed

Research Article

Frequent Alteration of MLL3 Frameshift Mutations in Microsatellite Deficient Colorectal Cancer

Yoshiyuki Watanabe ,

Contributed equally to this work with: Yoshiyuki Watanabe, Ryan J. Castoro

* E-mail: ponponta@marianna-u.ac.jp

Affiliations Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America, Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan
⨯
Ryan J. Castoro ,

Contributed equally to this work with: Yoshiyuki Watanabe, Ryan J. Castoro

Affiliation Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Hyun Soo Kim,

Affiliation Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Brittany North,

Affiliation Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Ritsuko Oikawa,

Affiliation Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan
⨯
Tetsuya Hiraishi,

Affiliation Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan
⨯
Saira S. Ahmed,

Affiliation Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Woonbok Chung,

Affiliation Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Mee-Yon Cho,

Affiliation Department of Pathology, Yonsei University Wonju College of Medicine, Wonju, Korea
⨯
Minoru Toyota,

Affiliation Department of Biochemistry, Sapporo Medical University, Sapporo, Hokkaido, Japan
⨯
Fumio Itoh,

Affiliation Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan
⨯
Marcos R. H. Estecio,

Affiliation Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Lanlan Shen,

Affiliation Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Jaroslav Jelinek,

Affiliation Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Jean-Pierre J. Issa

Affiliation Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
⨯

Frequent Alteration of MLL3 Frameshift Mutations in Microsatellite Deficient Colorectal Cancer

Yoshiyuki Watanabe,
Ryan J. Castoro,
Hyun Soo Kim,
Brittany North,
Ritsuko Oikawa,
Tetsuya Hiraishi,
Saira S. Ahmed,
Woonbok Chung,
Mee-Yon Cho,
Minoru Toyota

Published: August 11, 2011
https://doi.org/10.1371/journal.pone.0023320

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DNA methylation
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Frameshift mutation
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