About the Authors

Katherine E. Price

Affiliation Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

Giulia Orazi

Affiliation Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

Kathryn L. Ruoff

Affiliation Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

Wesley P. Hebert

Affiliation Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

George A. O’Toole

georgeo@dartmouth.edu (GAO); paul.mastoridis@novartis.com (PM)

Affiliation Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

Paul Mastoridis

georgeo@dartmouth.edu (GAO); paul.mastoridis@novartis.com (PM)

Affiliation Novartis Pharmaceutical Corporation, East Hanover, New Jersey, United States of America

Competing Interests

PM is an employee of Novartis Pharmaceutical Corporation, the manufacture of inhaled tobramycin. KEP, KLR, WPH and GAO declare no competing interests. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: PM GAO KEP. Performed the experiments: KLR WPH GO. Analyzed the data: KLR KEP GAO GO. Contributed reagents/materials/analysis tools: GAO. Wrote the paper: KEP GAO PM.