Temporary Dietary Iron Restriction Affects the Process of Thrombus Resolution in a Rat Model of Deep Vein Thrombosis

Makiko Oboshi; Yoshiro Naito; Hisashi Sawada; Shinichi Hirotani; Toshihiro Iwasaku; Yoshitaka Okuhara; Daisuke Morisawa; Akiyo Eguchi; Koichi Nishimura; Kenichi Fujii; Toshiaki Mano; Masaharu Ishihara; Tohru Masuyama

doi:10.1371/journal.pone.0126611

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Peer-reviewed

Research Article

Temporary Dietary Iron Restriction Affects the Process of Thrombus Resolution in a Rat Model of Deep Vein Thrombosis

Makiko Oboshi,

Affiliation Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
⨯
Yoshiro Naito ,

* E-mail: ynaito@hyo-med.ac.jp

Affiliation Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
⨯
Hisashi Sawada,

Affiliation Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
⨯
Shinichi Hirotani,

Affiliation Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
⨯
Toshihiro Iwasaku,

Affiliation Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
⨯
Yoshitaka Okuhara,

Affiliation Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
⨯
Daisuke Morisawa,

Affiliation Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
⨯
Akiyo Eguchi,

Affiliation Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
⨯
Koichi Nishimura,

Affiliation Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
⨯
Kenichi Fujii,

Affiliation Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
⨯
Toshiaki Mano,

Affiliation Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
⨯
Masaharu Ishihara,

Affiliation Division of Coronary Heart Disease, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
⨯
Tohru Masuyama

Affiliation Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
⨯

Temporary Dietary Iron Restriction Affects the Process of Thrombus Resolution in a Rat Model of Deep Vein Thrombosis

Makiko Oboshi,
Yoshiro Naito,
Hisashi Sawada,
Shinichi Hirotani,
Toshihiro Iwasaku,
Yoshitaka Okuhara,
Daisuke Morisawa,
Akiyo Eguchi,
Koichi Nishimura,
Kenichi Fujii

Published: May 11, 2015
https://doi.org/10.1371/journal.pone.0126611

About the Authors

Makiko Oboshi

Affiliation Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan

Yoshiro Naito

* E-mail: ynaito@hyo-med.ac.jp

Affiliation Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan

Hisashi Sawada

Affiliation Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan

Shinichi Hirotani

Affiliation Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan

Toshihiro Iwasaku

Affiliation Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan

Yoshitaka Okuhara

Affiliation Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan

Daisuke Morisawa

Affiliation Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan

Akiyo Eguchi

Affiliation Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan

Koichi Nishimura

Affiliation Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan

Kenichi Fujii

Affiliation Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan

Toshiaki Mano

Affiliation Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan

Masaharu Ishihara

Affiliation Division of Coronary Heart Disease, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan

Tohru Masuyama

Affiliation Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MO YN T. Masuyama. Performed the experiments: MO YN T. Masuyama HS SH TI YO DM AE KN KF T. Mano MI. Analyzed the data: MO YN HS T. Masuyama. Contributed reagents/materials/analysis tools: YN T. Masuyama. Wrote the paper: MO YN T. Masuyama.

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Deep vein thrombosis
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Diet
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Gene expression
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Collagens
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Thrombosis
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Vasculogenesis
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Oxidative stress
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Superoxides
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