About the Authors

Maria Ida Iacono

Affiliation Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland, 20993, United States of America

Esra Neufeld

Affiliation IT'IS Foundation for Research on Information Technologies in Society, Zurich, Switzerland

Esther Akinnagbe

Affiliation Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland, 20993, United States of America

Kelsey Bower

Affiliation Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland, 20993, United States of America

Johanna Wolf

Affiliations IT'IS Foundation for Research on Information Technologies in Society, Zurich, Switzerland, Swiss Federal Institute of Technology (ETH) Zurich, 8092 Zurich, Switzerland

Ioannis Vogiatzis Oikonomidis

Affiliations IT'IS Foundation for Research on Information Technologies in Society, Zurich, Switzerland, Swiss Federal Institute of Technology (ETH) Zurich, 8092 Zurich, Switzerland

Deepika Sharma

Affiliations IT'IS Foundation for Research on Information Technologies in Society, Zurich, Switzerland, Swiss Federal Institute of Technology (ETH) Zurich, 8092 Zurich, Switzerland

Bryn Lloyd

Affiliation IT'IS Foundation for Research on Information Technologies in Society, Zurich, Switzerland

Bertram J. Wilm

Affiliation Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland

Michael Wyss

Affiliation Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland

Klaas P. Pruessmann

Affiliation Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland

Andras Jakab

Affiliations Computational Imaging Research Laboratory, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Austria, Computer Vision Laboratory, ETH Zurich, Zurich, Switzerland

Nikos Makris

Affiliations Athinoula A. Martinos Center For Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, 02129, United States of America, Center for Morphometric Analysis, Department of Psychiatry and Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, 02129, United States of America

Ethan D. Cohen

Affiliation Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland, 20993, United States of America

Niels Kuster

Affiliations IT'IS Foundation for Research on Information Technologies in Society, Zurich, Switzerland, Swiss Federal Institute of Technology (ETH) Zurich, 8092 Zurich, Switzerland

Wolfgang Kainz

Affiliation Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland, 20993, United States of America

Leonardo M. Angelone

Leonardo.angelone@fda.hhs.gov

Affiliation Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland, 20993, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MII EN NK WK LMA. Performed the experiments: MII EN EA KB IVO DS BL AJ. Analyzed the data: MII EN LMA. Contributed reagents/materials/analysis tools: JW. Wrote the paper: MII EN EA EDC LMA. Helped with segmentation: EDC. Designed the MRI/MRA/DTI acquisition and acquired the data: BJW MW KP. Revised the segmentation: NM.