Epistasis as a Determinant of the HIV-1 Protease's Robustness to Mutation

Elena Capel; Mariona Parera; Miguel Angel Martinez

doi:10.1371/journal.pone.0116301

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Peer-reviewed

Research Article

Epistasis as a Determinant of the HIV-1 Protease's Robustness to Mutation

Elena Capel,

Current address: INSERM U1151 - CNRS UMR 8253, Université PARIS DESCARTES UMR_S 1151, Equipe 11: Pathogénie des Infections Systémiques, BATIMENT LERICHE – PORTE 9, 14 Rue Maria Helena Vieira Da Silva, CS61431, 75993, Paris, cedex 14, France

Affiliation Fundació irsiCaixa, Hospital Universitari Germans Trias i Pujol, Badalona, Universitat Autònoma de Barcelona, Barcelona, Spain
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Mariona Parera,

Affiliation Fundació irsiCaixa, Hospital Universitari Germans Trias i Pujol, Badalona, Universitat Autònoma de Barcelona, Barcelona, Spain
⨯
Miguel Angel Martinez

* E-mail: mmartinez@irsicaixa.es

Affiliation Fundació irsiCaixa, Hospital Universitari Germans Trias i Pujol, Badalona, Universitat Autònoma de Barcelona, Barcelona, Spain
⨯

Epistasis as a Determinant of the HIV-1 Protease's Robustness to Mutation

Elena Capel,
Mariona Parera,
Miguel Angel Martinez

Published: December 31, 2014
https://doi.org/10.1371/journal.pone.0116301

About the Authors

Elena Capel

Current address: INSERM U1151 - CNRS UMR 8253, Université PARIS DESCARTES UMR_S 1151, Equipe 11: Pathogénie des Infections Systémiques, BATIMENT LERICHE – PORTE 9, 14 Rue Maria Helena Vieira Da Silva, CS61431, 75993, Paris, cedex 14, France

Affiliation Fundació irsiCaixa, Hospital Universitari Germans Trias i Pujol, Badalona, Universitat Autònoma de Barcelona, Barcelona, Spain

Mariona Parera

Affiliation Fundació irsiCaixa, Hospital Universitari Germans Trias i Pujol, Badalona, Universitat Autònoma de Barcelona, Barcelona, Spain

Miguel Angel Martinez

* E-mail: mmartinez@irsicaixa.es

Affiliation Fundació irsiCaixa, Hospital Universitari Germans Trias i Pujol, Badalona, Universitat Autònoma de Barcelona, Barcelona, Spain

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EC MAM. Performed the experiments: EC MP. Analyzed the data: EC MAM. Wrote the paper: MAM.

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Proteases
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HIV-1
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Substitution mutation
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Point mutation
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Fitness epistasis
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Cloning
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Bacteriophages
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Epistasis
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