About the Authors

Nicholas S. Greaves

nickgreaves@doctors.org.uk (NSG); ardeshir.bayat@manchester.ac.uk (AB)

Affiliations Plastic and Reconstructive Surgery Research, Manchester Institute of Biotechnology (MIB), The University of Manchester, Manchester, Lancashire, United Kingdom, University Hospital of South Manchester NHS Foundation Trust, Wythenshawe Hospital, Manchester, Lancashire, United Kingdom

Julie Morris

Affiliation University Hospital of South Manchester NHS Foundation Trust, Wythenshawe Hospital, Manchester, Lancashire, United Kingdom

Brian Benatar

Affiliation Department of Histopatholgy, Pennine Acute Hospitals NHS Trust, Royal Oldham Hospital, Rochdale Road, Oldham, Lancashire, United Kingdom

Teresa Alonso-Rasgado

Affiliation School of Materials, University of Manchester, Manchester, Lancashire, United Kingdom

Mohamed Baguneid

Affiliation University Hospital of South Manchester NHS Foundation Trust, Wythenshawe Hospital, Manchester, Lancashire, United Kingdom

Ardeshir Bayat

nickgreaves@doctors.org.uk (NSG); ardeshir.bayat@manchester.ac.uk (AB)

Affiliations Plastic and Reconstructive Surgery Research, Manchester Institute of Biotechnology (MIB), The University of Manchester, Manchester, Lancashire, United Kingdom, Centre for Dermatology, Institute of Inflammation and Repair, Faculty of Medicine and Human Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom

Competing Interests

Tissue Regenix plc provided funding towards this study. The trial involves a National Health Service Blood and Transplant (Watford, UK) derived product that has been licensed to Tissue Regenix. Integra Matrix Wound Dressing samples were kindly provided by Integra LifeSciences (Plainsboro, NJ, USA). There are no further patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: NSG MB AB T-AR. Performed the experiments: NSG. Analyzed the data: NSG JM BB. Contributed reagents/materials/analysis tools: JM. Wrote the paper: NSG AB.