About the Authors

Bum-Ho Bin

Affiliation Bioscience Research Institute, Amorepacific Corporation R&D Center, Yongin, Republic of Korea

Jinhyuk Bhin

Affiliation Department of Chemical Engineering, POSTECH, Pohang, Republic of Korea

Seung Ha Yang

Affiliation Bioscience Research Institute, Amorepacific Corporation R&D Center, Yongin, Republic of Korea

Dong-Hwa Choi

Affiliation Gyeonggi Bio Center, Gyeonggi Institute of Science & Technology Promotion, Suwon, Republic of Korea

Kyuhee Park

Affiliation Gyeonggi Bio Center, Gyeonggi Institute of Science & Technology Promotion, Suwon, Republic of Korea

Dong Wook Shin

Affiliation Bioscience Research Institute, Amorepacific Corporation R&D Center, Yongin, Republic of Korea

Ai-Young Lee

Affiliation Department of Dermatology, Dongguk University Ilsan Hospital, Goyang, Republic of Korea

Daehee Hwang

Affiliation Department of Chemical Engineering, POSTECH, Pohang, Republic of Korea

Eun-Gyung Cho

egcho@amorepacific.com (EGC); TRLee@amorepacific.com (TRL)

Affiliation Bioscience Research Institute, Amorepacific Corporation R&D Center, Yongin, Republic of Korea

Tae Ryong Lee

egcho@amorepacific.com (EGC); TRLee@amorepacific.com (TRL)

Affiliation Bioscience Research Institute, Amorepacific Corporation R&D Center, Yongin, Republic of Korea

Competing Interests

Co-authors Bum-Ho Bin, Seung Ha Yang, Dong Wook Shin, Eun-Gyung Cho and Tae Ryong Lee are employed by Amorepacific Corporation R&D Center. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: BHB JHB SHY DHC KP. Performed the experiments: BHB JHB DWS AYL DH. Analyzed the data: BHB JHB DWS AYL DH. Contributed reagents/materials/analysis tools: BHB JHB. Wrote the paper: BHB JHB EGC TRL.