About the Authors

Chris Newby

Affiliations Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester, Leicester, United Kingdom, Department of Health Sciences, University of Leicester, Leicester, United Kingdom

Liam G. Heaney

Affiliation Centre for Infection and Immunity, Queen's University of Belfast, Belfast, United Kingdom

Andrew Menzies-Gow

Affiliation Royal Brompton Hospital, London, United Kingdom

Rob M. Niven

Affiliation North West Lung Centre, University of Manchester, Manchester, United Kingdom

Adel Mansur

Affiliation Severe and Brittle Asthma Unit, Birmingham Heartlands Hospital, Birmingham, United Kingdom

Christine Bucknall

Affiliation Department of Respiratory Medicine, Stobhill Hospital, Glasgow, United Kingdom

Rekha Chaudhuri

Affiliation Department of Respiratory Medicine, Division of Immunology, Infection and Inflammation, University of Glasgow and Gartnavel General, Glasgow, United Kingdom

John Thompson

Affiliation Department of Health Sciences, University of Leicester, Leicester, United Kingdom

Paul Burton

Affiliation Department of Health Sciences, University of Leicester, Leicester, United Kingdom

Chris Brightling

ceb17@le.ac.uk

Affiliation Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester, Leicester, United Kingdom

on behalf of the British Thoracic Society Severe Refractory Asthma Network

Competing Interests

Pilot funding for the Registry was provided as unrestricted research grants from Astra Zeneca, Glaxo Smith Kline and Novartis. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: CN C. Brightling PB JT LH. Analyzed the data: CN. Wrote the paper: CN C. Brightling. Contribution of data: LH AM-G RMN AM C. Bucknall RC C. Brightling. Editing manuscript: CN LH AM-G RMN AM C. Bucknall RC C. Brightling.