About the Authors

Marine Yeghiazaryan

Affiliation Department of Neurophysiology, The Nencki Institute of Experimental Biology, Warsaw, Poland

Izabela Rutkowska-Wlodarczyk

Affiliation Department of Molecular and Cellular Neurobiology, The Nencki Institute of Experimental Biology, Warsaw, Poland

Anna Konopka

Affiliation Department of Neurophysiology, The Nencki Institute of Experimental Biology, Warsaw, Poland

Grzegorz M. Wilczyński

Affiliation Department of Neurophysiology, The Nencki Institute of Experimental Biology, Warsaw, Poland

Armenuhi Melikyan

Affiliation D-Pharm Ltd, Kiryat Weizmann Science Park, Rehovot, Israel

Eduard Korkotian

Affiliation Department of Neurobiology, Weizmann Institute, Rehovot, Israel

Leszek Kaczmarek

Affiliation Department of Molecular and Cellular Neurobiology, The Nencki Institute of Experimental Biology, Warsaw, Poland

Izabela Figiel

i.figiel@nencki.gov.pl

Affiliation Department of Molecular and Cellular Neurobiology, The Nencki Institute of Experimental Biology, Warsaw, Poland

Competing Interests

The authors declare that Armenuh Melikyan is an employee of D-Pharm and that D-Pharm provided the test compounds, free of charge, under a material transfer agreement, to the Kaczmarek group in Poland. D-Pharm has been, and is currently developing DP-b99 for acute ischemic stroke and acute pancreatitis, respectively. D-Pharm is currently sponsoring a small Phase 2 clinical trial in acute pancreatitis. D-Pharm and the Kaczmarek group were previously part of the FP7 funded Plasticise consortium, under whose auspices the collaboration originally started. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: LK GMW. Performed the experiments: MY IF AK EK. Analyzed the data: MY IF IR-W AM. Contributed reagents/materials/analysis tools: LK GMW AM EK. Wrote the paper: LK GMW IF MY IR-W. Obtained permission for use animals: MY IF.